Only Sims and Kyle were left when they were able to enter the church. Unfortunately Sims lost all his men after Father Bella, the mastermind behind the drug, threw grenades at them while simultaneously a small army of Glowheads attacked them. When Sims traced the source of GLOW to a church in Little Italy during the city riots, Sims along with Kyle and whatever officers he had left attempted to storm the church. Sims also sought to arrest Cody for using GLOW, a highly addictive drug that increases the physical attributes of the user. He wanted Kyle not to get involved due to the danger Cody was in. By the request of his sister, Vanessa, he assisted her boyfriend, Kyle into looking for his missing brother.
When Kyle’s brother, Cody, is taken captive by The Stiff in her bar, Vanessa does her best to provide information and ideas to Kyle to find Cody.
The arcade mode is a no-frills 3D brawler for 1 or 2 players. An 'instinct' system allows players to counter opponents' attacks, as well as make their attacks more powerful. Players earn money through pit fights and side missions, upgrading Kyle's moveset by training in various gyms in Metro City while progressing through the game. The story mode, which is exclusively single player, has ten minigames, including cockroach stomping, arm-wrestling, slide puzzles, shooting contests and the classic car bash.
Final Fight: Streetwise is a 3D beat 'em up game.